Skin Cancer


Despite significant increases in the numbers of people surviving cancer, there yet exists a vastrift in the number who die each year despite treatment. It remains one of the most challenging diseases to treat, in part, due to the heterogeneity of the malady.
Most cancers originate as a single cell, and thus monoclonal in origin, however, due to innate genetic instability of subsequent cell generations, new characteristics create a heterogenic disease well-defined by genetic clonal expansion epigenetic changes favoring phenotypic diversity.
However, cancer cells are not the only contributors to tumor heterogeneity. There exists a reciprocal and dynamic interaction between the microenvironment constituents, such as infiltrating cells, andjuxtapositoned matrices and cells to produce a distinct tumor phenotype.
The clinical relevance is that this tumorheterogeneity contributes significantly to the efficacy of drug therapy and therefore imparts considerable inter-individual variation in pharmacotherapy and clinical response to a myriad of   medications. Thus, this divergence underscores the necessity to personalize therapeutic regimens.
The world wide skin cancer day was celebrated in the month of May. Many awareness programmes are undertaken to avoid skin cancer. These mainly occur due to the excess use of more chemical products to the skin and these spread to other body parts like arms, legs, nose and other prominent organs of the body .
Many treatments are there for the skin cancer there are Mohs Micrographic Surgery, Excisional Surgery, Electro surgery, Cryosurgery, Radiation, Photodynamic Therapy, Laser Surgery, Topical Medications. etc, Some will go with ayurvedic and homeopathy medicines which will cure but time will taken and should be used for lifelong time
The above Article originally got published at SciFed Oncology and Cancer Research Journal in 2017, to have a glance please visit: Click Here

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Fight the Fight Find the Cure

            

            Breast Cancer is cancer which develops from the breast tissue Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, fluid coming from the nipple, or a red scaly patch of skin. In those with distant spread of disease, there may be bone pain, swollen lymph nodes, shortness of breath, or yellow skin.
            Bisphosphonates are commonly used in the treatment of osteoporosis and metastatic bone disease. Their mechanism of action involves the inhibition of the osteoclast activity leading to the reduction of bone resorption. Their activity reduces the incidence of skeletal complications, such as fractures, pains, and hypocalcaemia. Nowadays among the different Bisphosphonates Zoledronate is largely used because of its relative higher potency and short infusion time. Zoledronate is usually well tolerated; well known side effects of Zoledronate include, fatigue, fever, myalgia or arthralgia, nausea, bone pains, and elevation in serum creatinine .Retrospective studies have reported an association between long-term Bisphosphonates therapy and osteonecrosis of the jaw .Ocular adverse events have been reported with nitrogen-containing Bisphosphonates with unclear underlying mechanisms. No ocular factors or predispositions are known. The inflammations could be explained with the release of elevated levels of cytokines, including tumor necrosis factor and interleukin 6.
            Breast cancer prevention starts with healthy habits such as limiting alcohol and staying physically active some risk factors, such as family history, can't be changed. However, there are lifestyle changes you can make to lower your risk, Limit dose and duration of hormone therapy, Avoid exposure to radiation and environmental pollution.
            The world breast cancer  day was celebrated on October 20 every year on this many scientists and doctors will promote the awareness of breast cancer and many programmers are conducted on this day to give hands to the patients who suffering with breast cancer

            The above Article originally got published at SciFed Oncology and Cancer ResearchJournal in 2017, to have a glance please visit: Click Here

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