Skin Cancer


Despite significant increases in the numbers of people surviving cancer, there yet exists a vastrift in the number who die each year despite treatment. It remains one of the most challenging diseases to treat, in part, due to the heterogeneity of the malady.
Most cancers originate as a single cell, and thus monoclonal in origin, however, due to innate genetic instability of subsequent cell generations, new characteristics create a heterogenic disease well-defined by genetic clonal expansion epigenetic changes favoring phenotypic diversity.
However, cancer cells are not the only contributors to tumor heterogeneity. There exists a reciprocal and dynamic interaction between the microenvironment constituents, such as infiltrating cells, andjuxtapositoned matrices and cells to produce a distinct tumor phenotype.
The clinical relevance is that this tumorheterogeneity contributes significantly to the efficacy of drug therapy and therefore imparts considerable inter-individual variation in pharmacotherapy and clinical response to a myriad of   medications. Thus, this divergence underscores the necessity to personalize therapeutic regimens.
The world wide skin cancer day was celebrated in the month of May. Many awareness programmes are undertaken to avoid skin cancer. These mainly occur due to the excess use of more chemical products to the skin and these spread to other body parts like arms, legs, nose and other prominent organs of the body .
Many treatments are there for the skin cancer there are Mohs Micrographic Surgery, Excisional Surgery, Electro surgery, Cryosurgery, Radiation, Photodynamic Therapy, Laser Surgery, Topical Medications. etc, Some will go with ayurvedic and homeopathy medicines which will cure but time will taken and should be used for lifelong time
The above Article originally got published at SciFed Oncology and Cancer Research Journal in 2017, to have a glance please visit: Click Here
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Fight the Fight Find the Cure

            

            Breast Cancer is cancer which develops from the breast tissue Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, fluid coming from the nipple, or a red scaly patch of skin. In those with distant spread of disease, there may be bone pain, swollen lymph nodes, shortness of breath, or yellow skin.
            Bisphosphonates are commonly used in the treatment of osteoporosis and metastatic bone disease. Their mechanism of action involves the inhibition of the osteoclast activity leading to the reduction of bone resorption. Their activity reduces the incidence of skeletal complications, such as fractures, pains, and hypocalcaemia. Nowadays among the different Bisphosphonates Zoledronate is largely used because of its relative higher potency and short infusion time. Zoledronate is usually well tolerated; well known side effects of Zoledronate include, fatigue, fever, myalgia or arthralgia, nausea, bone pains, and elevation in serum creatinine .Retrospective studies have reported an association between long-term Bisphosphonates therapy and osteonecrosis of the jaw .Ocular adverse events have been reported with nitrogen-containing Bisphosphonates with unclear underlying mechanisms. No ocular factors or predispositions are known. The inflammations could be explained with the release of elevated levels of cytokines, including tumor necrosis factor and interleukin 6.
            Breast cancer prevention starts with healthy habits such as limiting alcohol and staying physically active some risk factors, such as family history, can't be changed. However, there are lifestyle changes you can make to lower your risk, Limit dose and duration of hormone therapy, Avoid exposure to radiation and environmental pollution.
            The world breast cancer  day was celebrated on October 20 every year on this many scientists and doctors will promote the awareness of breast cancer and many programmers are conducted on this day to give hands to the patients who suffering with breast cancer

            The above Article originally got published at SciFed Oncology and Cancer ResearchJournal in 2017, to have a glance please visit: Click Here
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Endometrial Stromal Tumors


The cause of development of Endometrial Stromal Tumor is related to genetic abnormalities. The tumor is known to originate from the endometrial stroma, in many cases. The gene mutations and chromosomal alterations are specific to the subtype of EST.
Endometrial Stromal Tumors may be benign or malignant. Some women may not show any signs and symptoms. In others, the signs and symptoms of EST may include:
The presence of a solitary, small or large tumor; the majority are between 5-10 cm in size
Generally, malignant tumors have poorly-defined boundaries; while, benign tumors are mostly well-defined
Sensation of pelvic mass or enlarged uterus
Most of the tumors are located intramurally (i.e., found within the uterine walls)
In some cases, polypoid tumors are observed
Heavy or abnormal bleeding from the uterus and abdominal pain are both common symptoms in women with EST
Signs and symptoms may also occur from large-sized tumors causing compression of adjoining uterine structures including frequent urination and lower back pain
Pain during sexual intercourse
The diagnosis of Endometrial Stromal Tumor may involve:
Complete physical examination with thorough evaluation of medical history
Ultrasound scan of the pelvis: It is a noninvasive procedure that uses high frequency sound waves to produce real-time images
Abdominal and pelvic CT scan: It is a noninvasive procedure that provides more details of soft tissues, blood vessels, and internal organs
Pelvic MRI scan: It is a noninvasive medical test that uses a powerful magnetic field to produce images of soft tissues, bones, organs, and all other internal structures of the abdomen and pelvis


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Pancreatic Ductal Adenocarcinoma (PDAC)


Cancer is a "group of diseases characterized by unregulated cell growth and differentiation”. Pancreatic carcinoma usually starts once cells within the pancreas begin to grow uncontrollably. Pancreatic Carcinoma mainly occur in the states Europe and  united States of America, About 60% of the people are suffering from this Pancreatic Cancer, recent studies state that by the end of 2030 the rate Pancreatic cancer will be increased and this cancer will be in leading positions for causing death of the many innocent people.
 The main causes of pancreatic cancer are Jaundice, chronic pancreatitis, Unrelenting pain in the upper belly, Abdominal Pain, back pain, dark colored urine(prior to stent), elevated billirubin, constipation, fatigue, weight loss (15 lbs), swollen feet, painful digestion some days, Numbness on left side slight back pain etc,,
There are four stages of pancreatic cancer they are:
The cancer has not grown outside the pancreas and is 2 centimeters (cm) (about ¾ inch) or less across.
The cancer has not grown outside the pancreas but is larger than 2 cm across.
The cancer has grown outside the pancreas into nearby surrounding structures but not into major blood vessels or nerves.
The cancer has grown beyond the pancreas into nearby large blood vessels or nerves.
The Fourth stage is the dangerous one in rare cases the cancer will be cure in the second stage. As this is very dangerous cancer there is no proper cure for this cancer only is take preventive measures like need to quit smoking and drinking of alcohol, proper exercise, maintenance of healthy weight, etc.
This cancer cannot be cured but many attempts like chemotherapy, Radiotherapy, Surgery, Clinical care, and also palliative care should be taken to the patient.
Chemotherapy will help in the killing of cancer cells with the help of drugs these drugs can be injected through or by orally we can take these drugs. Whereas Radiotherapy means these use high energy source like X-rays, protons to destroy the cancer cells. Clinical trials are studies to test new treatments, such as systemic therapy, and new approaches to surgery or radiation therapy. 
 Integrative medicine and alternative therapies may also help you cope with distress. Examples include: Art therapy, Exercise, Meditation, Music therapy, Relaxation exercises, Spirituality.

We are very thankful for giving this Article by Dr Ahmed M. Kabel. The above Article originally got published at SciFed Oncology and Cancer Research Journal in 2017, To have a glance please visit: Click Here
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WALKING AGAINST TUMORS






The Oncology & Cancer Research Journal is a peer reviewed journal which aims to serve its readers as an authoritative resource on the profession and practice of Oncology & Cancer Research. Which was published in the year 2016.
     we have well educated and fully knowledged editorial board members of more than  Thirty who came from the topmost universities and institutes like Sherry Bradford President, Yanka Kupala State University of Grodno,   University of Rijeka,  University of Zakho, University of Texas,  Mansoura University, Public Hospital in Dolo, University of Munster,  SRL Diagnostic Lab, N.N. Alexandrov National Cancer Center, Jagiellonian University, rana.ahmed-youness, Cairo University Medical school, NMIMS University, dracarolinahernandez, Deakin University,  Yonsei University College of Medicine, Nanjing University, University of Tsukuba, National Cancer Institute, Emory University, Sao Leopoldo Mandic medical school, Imperial College, National Kaohsiung University of Applied Sciences , Charite University Clinic, LiaquatUniversity of Medical & Health Sciences, Amity Institute of Virology & Immunology,  National University of Singapore, AIN SHAMS UNIVERSITY Binafsha Manzoor Syed, Dnepropetrovsk Medical Academy, Charles Darwin University, Instituto de Radioterapia, Peoples University Nicholas Copernicus,  Hebei Medical University, Dalian Medical University. These all delegates came from the topmost universities and institutes in the countries like Brazil, United States Of America, Italy, Australia, Belarus, Croatia, Iraq, Egypt, Germany, India, Krakow, South Korea, China, Japan, London, Taiwan, Pakistan, Singapore.

     The following watch words in carcinogenesis - etiology, mechanisms, molecular biology, recent developments in tumor therapy, general diagnosis; laboratory diagnosis, diagnostic and experimental pathology, oncologic surgery, and epidemiology.

    Oncology research can be broadly divided into basic oncology and applied oncology. Oncologists are specialized in treating cancer and play a crucial role in the diagnosis of the type and the stage of cancer, which sets the stage for treatment.
     As cancer is  a very dangerous  diseases which  kill many people without knowing them.
As we are forecasting this message to the busy world who don’t know about this evil disease. In our website we are doing  all varieties of manuscripts such as research article, review, mini review, rapid communications, case reports & letter to editors, short communications, image article, videos & graphical presentations and editorials are given prominence.
So please come forward to help us for improving better.
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